Which of the following is a minor Duke criterion?

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Predisposing heart condition or IV drug use is a minor Duke criterion. In the Duke criteria for infective endocarditis, findings are split into major and minor categories. Major criteria reflect strong evidence of infection of the endocardium, such as direct imaging of vegetation on an echocardiogram or new valvular regurgitation, or microbiologic proof from blood cultures that meets specific criteria (typically two positive cultures with a typical organism). Minor criteria include factors that raise suspicion but aren’t by themselves diagnostic, such as having a predisposing heart condition or IV drug use, fever, vascular or immunologic phenomena, or microbiologic evidence that does not meet major criteria. So the risk factor of a predisposing condition fits as a minor criterion, whereas showing vegetation on echo or a new regurgitation demonstrates endocardial involvement and counts as major. A positive blood culture can be microbiologic evidence but usually needs to meet the major criteria conditions (e.g., two positive cultures) to be considered a major criterion; otherwise it remains supportive microbiologic evidence rather than a defining major criterion.