Which diuretic is most commonly associated with gynecomastia?

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Multiple Choice

Which diuretic is most commonly associated with gynecomastia?

Gynecomastia results from an imbalance between estrogen and androgen activity in the male breast tissue. Spironolactone is a potassium-sparing diuretic that blocks the androgen receptor and can reduce androgen production, creating relatively less androgen effect and relatively more estrogen effect. That hormonal shift promotes breast tissue growth, making gynecomastia a well-known, dose-related side effect of spironolactone. The other diuretics listed lack significant antiandrogenic activity, so they do not commonly cause this change in male breast tissue.

Gynecomastia results from an imbalance between estrogen and androgen activity in the male breast tissue. Spironolactone is a potassium-sparing diuretic that blocks the androgen receptor and can reduce androgen production, creating relatively less androgen effect and relatively more estrogen effect. That hormonal shift promotes breast tissue growth, making gynecomastia a well-known, dose-related side effect of spironolactone. The other diuretics listed lack significant antiandrogenic activity, so they do not commonly cause this change in male breast tissue.

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