What valvular disorder is most commonly associated with Marfan's Syndrome?

Study for the PANCE Cardiology Test. Enhance your knowledge with comprehensive flashcards and multiple-choice questions. Each question comes with hints and detailed explanations. Prepare thoroughly for your exam!

In Marfan syndrome the aorta often undergoes dilation due to cystic medial degeneration from a defect in connective tissue (fibrillin-1). When the aortic root enlarges, the aortic valve leaflets can no longer coapt properly during diastole, allowing blood to leak back into the left ventricle. This creates aortic regurgitation, which is the most commonly associated valvular problem in Marfan patients. You’ll often see a wide pulse pressure and an early diastolic decrescendo murmur best heard along the left sternal border, and it may be accentuated when the patient leans forward. Mitral valve involvement, such as mitral valve prolapse with mitral regurgitation, can occur but is less characteristic than AR in Marfan. Aortic stenosis or tricuspid stenosis are not typical features of Marfan-related valvular disease.